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robbi76_ Inserito il - 10 gennaio 2017 : 18:36:02
Hair Regeneration Treatment Using
Adipose-Derived Stem Cell Conditioned Medium:
Follow-up With Trichograms
Hirotaro Fukuoka, MD, PhD, and Hirotaka Suga, MD, PhD
Cherry-Blossom Plastic and Regenerative Surgery, Tokyo, Japan; and Department of Plastic and
Reconstructive Surgery, Kyorin University, Tokyo, Japan.
Correspondence:
taro@minato-cl.co.jp

Keywords: alopecia, adipose-derived stem cells, conditioned medium, trichograms, half-side
comparison study Published March 26, 2015
Objective: Adipose-derived stem cells secrete various growth factors that promote
hair growth. This study examined the effects of adipose-derived stem cell-conditioned
medium on alopecia. Methods: Adipose-derived stem cell-conditioned medium was
intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients
received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were
counted using trichograms before and after treatment. A half-side comparison study
was also performed in 10 patients (8 men and 2 women). Results: Hair numbers were
significantly increased after treatment in both male (including those without finasteride
administration) and female patients. In the half-side comparison study, the increase in
hair numbers was significantly higher on the treatment side than on the placebo side.
Conclusion: Treatment using adipose-derived stem cell-conditioned medium appears
highly effective for alopecia and may represent a new therapy for hair regeneration.
Conservative treatments for alopecia include oral administration of finasteride and
topical administration of minoxidil. However, these conventional therapies are ineffective
in some patients. Furthermore, finasteride administration is indicated only for androgenic
alopecia and is therefore applied only in male patients. New therapies that are both more
effective and able to be used in female patients are required.
Adipose-derived stem cells are multipotent cells that have shown potential for regenerative
medicine.1 Adipose-derived stem cells not only differentiate into mesenchymal
lineage cells but also secrete various growth factors.2,3 Recent studies have reported that
adipose-derived stem cells promote hair growth via growth factor secretion.4,5 We have
already used adipose-derived stem cell-conditioned medium to treat alopecia and reported
good results.6,7

In this study, to obtain more objective data, we examined changes in hair numbers
as measured using trichograms and evaluated the effects of adipose-derived stem cellconditioned
medium on hair regeneration.
METHODS
Patients
The study followed principles in the Declaration of Helsinki. Twenty-two patients (11 men
and 11 women; age range, 20-70 years) with alopecia were treated with adipose-derived
stem cell-conditioned medium and examined with trichograms both before starting and after
completing treatment. In the other group of 10 patients (8 men and 2 women; age range,
20-73 years), a half-side comparison study was performed as described later. Informed
consent was obtained from all patients prior to enrolment in the study.
Treatment
We used a commercial product containing protein solution from adipose-derived stem
cell-conditioned medium (AAPE; Prostemics, Seoul, Korea), as previously described.6,7
AAPER
was well studied in the previous report and it contains various growth factors
or cytokines such as hepatocyte growth factor, fibroblast growth factor–1, granulocyte
colony-stimulating factor, granulocyte macrophage-colony-stimulating factor, interleukin
6, vascular endothelial growth factor, and transforming growth factor ß3.8 Intradermal
injections with a 31-G needle provided about 0.02 mL/cm2 of solution. A total volume of
3 to 4 mL was injected during each session of treatment. Patients received treatment every
3 to 5 weeks for a total of 6 sessions. Finasteride was also administered to 6 male patients,
but no female patients, during the study.
Trichograms
The intersection of a line extending cranially from the lateral angle of an eye (left or right)
and a line connecting both ears coronally was marked on the scalp with tattoo. A circle 2
cm in diameter centered on this mark was shaved. TrichoScope images were recorded using
a PowerShot 450 digital camera (Canon, Tokyo, Japan). The number of hairs within a circle
of 11 mm in diameter (area, 95 mm2) centered on the tattoo was counted by 2 technicians
blind to the patients, and the average number was recorded as data. Trichograms were made
before starting treatment and at 1 to 3 months after the final treatment (7 to 12 months after
initial treatment).
Half-side comparison study
After providing informed consent, 10 patients (8 men and 2 women; age range, 20-73
years) received adipose-derived stem cell-conditioned medium treatment on the left side
and placebo treatment (saline injection) on the right. Treatment was again performed
every 3 to 5 weeks for a total of 6 sessions. Both sides of the scalp were examined
66
FUKUOKA ET AL
using trichograms before starting treatment and after treatment. None of the patients were
administered finasteride during this study.
Statistical analysis
Data are expressed as mean ± standard error of the mean. Data before and after treatment,
or data from both sides in the half-side comparison, were compared using the Wilcoxon
signed rank test. Values of P < .05 were considered statistically significant.
RESULTS
Numbers of hairs in the same area of the same patient were accurately counted using
trichograms before and after treatment (Fig 1). The number of hairs increased significantly
after treatment in both male (n = 11) and female (n = 11) patients (Fig 2). The mean increase
in the number of hairs was 29 ± 4.1 in male patients and 15.6 ± 4.2 in female patients.
No significant difference was observed between men and women. In male patients, groups
with (n = 6) and without (n = 5) finasteride administration were compared. The number of
hairs increased significantly after treatment in both groups (Fig 3). No significant difference
was observed between groups with or without finasteride administration. Representative
clinical courses are shown in Figure 4 (a male patient) and Figure 5 (a female patient).
Figure 1. TrichoScope images of a 24-year-old male patient.
(A) Before treatment. The number of hairs in the circle is
126. (B) After treatment (7 months after initial treatment).
The number of hairs in the circle is 141.
In the half-side comparison study, the number of hairs was significantly increased
after treatment on both the left (adipose-derived stem cell-conditioned medium) and right
(placebo) sides (Fig 6). However, the increase in the number of hairs was significantly
higher on the left (adipose-derived stem cell-conditioned medium) side than on the right
(placebo) side (Fig 7).
DISCUSSION
This study used trichograms to objectively show the positive effects of adipose-derived
stem cell-conditioned medium on alopecia. To obtain accurate data, shaving and marking
the area for the trichogram is important. We believe that trichograms, particularly as used
67
ePlasty VOLUME 15
in this study, offer a reliable and useful method for assessing the treatment of alopecia,
although the method is semi-invasive for patients.
Figure 2. Changes in the number of hairs before
and after treatment in male and female patients.
*P < .01.
Figure 3. Changes in the number of hairs before
and after treatment in male patients with or
without finasteride administration. *P < .05.
Treatment with adipose-derived stem cell-conditioned medium was effective, even in
patients who did not take finasteride. We believe that this treatment may offer an alternative
to finasteride administration and thus appears particularly useful for female patients. Although
no significant difference in improvement of alopecia was seen between male patients
treated using adipose-derived stem cell-conditioned medium with and without finasteride
administration, we got the impression that the combination of adipose-derived stem cellconditioned
medium and finasteride is preferable to single treatment. The combination
therapy was effective in our previous study as well.6 We believe that hairs are regulated
by various factors, including androgen and cytokines. The efficacy of combination therapy
should be elucidated in a future study.
68
FUKUOKA ET AL
Figure 4. A 49-year-old male patient. (A) Before treatment. (B) During
treatment (4 months after initial treatment). (C) After treatment (10 months
after initial treatment). (D) Final follow-up (2 years and 1 month after initial
treatment).
Adipose-derived stem cell-conditioned medium is rich in growth factors such as vascular
endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor,
and insulin-like growth factor 1.2,9 Vascular endothelial growth factor controls hair growth
and follicle size through angiogenesis.10 Hepatocyte growth factor is involved in the cyclic
growth of hair follicles.11,12 Platelet-derived growth factor induces and maintains the anagen
phase of hair follicles.13 Insulin-like growth factor 1 controls the hair growth cycle
and differentiation of hair shafts.14 In treatment with adipose-derived stem cell-conditioned
medium, each growth factor seems likely to activate hair follicles and contribute to increasing
the number of hairs in patients with alopecia. Because growth factors dose-dependently
69
ePlasty VOLUME 15
affect cells, the dose dependence of the effects of adipose-derived stem cell-conditioned
medium on alopecia should be examined in a future study.
In the half-side comparison study, the finding that the number of hairs increased even
on the right (placebo) side was somewhat surprising. This result might suggest that the
injection itself activates hair growth via tissue injury, or that adipose-derived stem cellconditioned
medium injected on one side can affect the other side, perhaps through the
local circulation.
Figure 5. A 44-year-old female patient. (A) Before treatment. (B) After treatment (7
months after initial treatment). (C) Final follow-up (1 year and 10 months after initial
treatment).
Figure 6. Changes in the number of hairs before
and after treatment in the half-side comparison

Figure 6. Changes in the number of hairs before
and after treatment in the half-side comparison
study. *P < .05 and †P < .01.
70
FUKUOKA ET AL
Figure 7. Increases in the
number of hairs in the
half-side comparison study.
*P < .01.
Contraindications for adipose-derived stem cell-conditioned medium treatment are
similar to those for general mesotherapy, including local skin disease, inflammation, infection,
allergic disease, autoimmune disease, pregnancy, cancer, and current anticoagulant
therapy. The most common complication is pain during and after injection, but this can be
prevented or managed with supraorbital nerve block, occipital nerve block, local anesthesia,
cooling, or administration of nonsteroidal anti-inflammatory drugs.
In conclusion, treatment using adipose-derived stem cell-conditioned medium appears
highly effective for alopecia and may represent a new avenue of therapy for hair regeneration.
More details about adipose-derived stem cell-conditioned medium treatment, such as longterm
(over a period of years) effects and histological changes, should be elucidated in the
future.
REFERENCES
1. Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res.
2007;100:1249-60.
2. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose
stromal cells. Circulation. 2004;109:1292-8.
3. Suga H, Eto H, Shigeura T, et al. IFATS collection: fibroblast growth factor-2-induced hepatocyte growth
factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal
kinase-dependent mechanism. Stem Cells. 2009;27:238-49.
4. Wong CH, Yoo HG, Kwon OS, et al. Hair growth promoting effects of adipose tissue-derived stem cells. J
Dermatol Sci. 2010;57:134-7.
5. Festa E, Fretz J, Ryan B, et al. Adipocyte lineage cells contribute to the skin stem cell niche to drive hair
cycling. Cell. 2011;146:761-71.
6. Fukuoka H, Suga H. Hair regeneration treatment using stem cell conditioned medium. Jpn J Plast Surg.
2012;55:1083-9.
7. Fukuoka H, Suga H, Narita K, Watanabe R, Shintani S. The latest advance in hair regeneration therapy
using proteins secreted by adipose-derived stem cells. Am J Cosmet Surg. 2012;29:273-82.
8. Moon KM, Park YH, Lee JS, et al. The effect of secretory factors of adipose-derived stem cells on human
keratinocytes. Int J Mol Sci. 2012;13:1239-57.
9. Park BS, Kim WS, Choi JS, et al. Hair growth stimulated by conditioned medium of adipose-derived stem
cells is enhanced by hypoxia: evidence of increased growth factor secretion. Biomed Res. 2010;31:27-34.
71
ePlasty VOLUME 15
10. Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis.
J Clin Invest. 2001;107:409-17.
11. Jindo T, Tsuboi R, Takamori K, Ogawa H. Local injection of hepatocyte growth factor/scatter factor
(HGF/SF) alters cyclic growth of murine hair follicles. J Invest Dermatol. 1998;110:338-42.
12. Lindner G, Menrad A, Gherardi E, et al. Involvement of hepatocyte growth factor/scatter factor and met
receptor signaling in hair follicle morphogenesis and cycling. FASEB J. 2000;14:319-32.
13. Tomita Y, Akiyama M, Shimizu H. PDGF isoforms induce and maintain anagen phage of murine hair
follicles. J Dermatol Sci. 2006;43:105-15.
14. Weger N, Schlake T. Igf-1 signalling controls the hair growth cycle and the differentiation of hair shafts. J
4   U L T I M E    R I S P O S T E    (in alto le pi� recenti)
robbi76_ Inserito il - 12 gennaio 2017 : 21:58:01
scusatemi: di questo volevo discutere

Hair Regeneration Treatment Using
Adipose-Derived Stem Cell Conditioned Medium:
Follow-up With Trichograms
Hirotaro Fukuoka, MD, PhD, and Hirotaka Suga, MD, PhD
Cherry-Blossom Plastic and Regenerative Surgery, Tokyo, Japan; and Department of Plastic and
Reconstructive Surgery, Kyorin University, Tokyo, Japan.
Correspondence: taro@minato-cl.co.jp
Keywords: alopecia, adipose-derived stem cells, conditioned medium, trichograms, half-side
comparison study Published March 26, 2015
Objective: Adipose-derived stem cells secrete various growth factors that promote
hair growth. This study examined the effects of adipose-derived stem cell-conditioned
medium on alopecia. Methods: Adipose-derived stem cell-conditioned medium was
intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients
received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were
counted using trichograms before and after treatment. A half-side comparison study
was also performed in 10 patients (8 men and 2 women). Results: Hair numbers were
significantly increased after treatment in both male (including those without finasteride
administration) and female patients. In the half-side comparison study, the increase in
hair numbers was significantly higher on the treatment side than on the placebo side.
Conclusion: Treatment using adipose-derived stem cell-conditioned medium appears
highly effective for alopecia and may represent a new therapy for hair regeneration.
Conservative treatments for alopecia include oral administration of finasteride and
topical administration of minoxidil. However, these conventional therapies are ineffective
in some patients. Furthermore, finasteride administration is indicated only for androgenic
alopecia and is therefore applied only in male patients. New therapies that are both more
effective and able to be used in female patients are required.
Adipose-derived stem cells are multipotent cells that have shown potential for regenerative
medicine.1 Adipose-derived stem cells not only differentiate into mesenchymal
lineage cells but also secrete various growth factors.2,3 Recent studies have reported that
adipose-derived stem cells promote hair growth via growth factor secretion.4,5 We have
already used adipose-derived stem cell-conditioned medium to treat alopecia and reported
good results.6,7

In this study, to obtain more objective data, we examined changes in hair numbers
as measured using trichograms and evaluated the effects of adipose-derived stem cellconditioned
medium on hair regeneration.
METHODS
Patients
The study followed principles in the Declaration of Helsinki. Twenty-two patients (11 men
and 11 women; age range, 20-70 years) with alopecia were treated with adipose-derived
stem cell-conditioned medium and examined with trichograms both before starting and after
completing treatment. In the other group of 10 patients (8 men and 2 women; age range,
20-73 years), a half-side comparison study was performed as described later. Informed
consent was obtained from all patients prior to enrolment in the study.
Treatment
We used a commercial product containing protein solution from adipose-derived stem
cell-conditioned medium (AAPE; Prostemics, Seoul, Korea), as previously described.6,7
AAPER
was well studied in the previous report and it contains various growth factors
or cytokines such as hepatocyte growth factor, fibroblast growth factor–1, granulocyte
colony-stimulating factor, granulocyte macrophage-colony-stimulating factor, interleukin
6, vascular endothelial growth factor, and transforming growth factor ß3.8 Intradermal
injections with a 31-G needle provided about 0.02 mL/cm2 of solution. A total volume of
3 to 4 mL was injected during each session of treatment. Patients received treatment every
3 to 5 weeks for a total of 6 sessions. Finasteride was also administered to 6 male patients,
but no female patients, during the study.
Trichograms
The intersection of a line extending cranially from the lateral angle of an eye (left or right)
and a line connecting both ears coronally was marked on the scalp with tattoo. A circle 2
cm in diameter centered on this mark was shaved. TrichoScope images were recorded using
a PowerShot 450 digital camera (Canon, Tokyo, Japan). The number of hairs within a circle
of 11 mm in diameter (area, 95 mm2) centered on the tattoo was counted by 2 technicians
blind to the patients, and the average number was recorded as data. Trichograms were made
before starting treatment and at 1 to 3 months after the final treatment (7 to 12 months after
initial treatment).
Half-side comparison study
After providing informed consent, 10 patients (8 men and 2 women; age range, 20-73
years) received adipose-derived stem cell-conditioned medium treatment on the left side
and placebo treatment (saline injection) on the right. Treatment was again performed
every 3 to 5 weeks for a total of 6 sessions. Both sides of the scalp were examined
66
FUKUOKA ET AL
using trichograms before starting treatment and after treatment. None of the patients were
administered finasteride during this study.
Statistical analysis
Data are expressed as mean ± standard error of the mean. Data before and after treatment,
or data from both sides in the half-side comparison, were compared using the Wilcoxon
signed rank test. Values of P < .05 were considered statistically significant.
RESULTS
Numbers of hairs in the same area of the same patient were accurately counted using
trichograms before and after treatment (Fig 1). The number of hairs increased significantly
after treatment in both male (n = 11) and female (n = 11) patients (Fig 2). The mean increase
in the number of hairs was 29 ± 4.1 in male patients and 15.6 ± 4.2 in female patients.
No significant difference was observed between men and women. In male patients, groups
with (n = 6) and without (n = 5) finasteride administration were compared. The number of
hairs increased significantly after treatment in both groups (Fig 3). No significant difference
was observed between groups with or without finasteride administration. Representative
clinical courses are shown in Figure 4 (a male patient) and Figure 5 (a female patient).
Figure 1. TrichoScope images of a 24-year-old male patient.
(A) Before treatment. The number of hairs in the circle is
126. (B) After treatment (7 months after initial treatment).
The number of hairs in the circle is 141.
In the half-side comparison study, the number of hairs was significantly increased
after treatment on both the left (adipose-derived stem cell-conditioned medium) and right
(placebo) sides (Fig 6). However, the increase in the number of hairs was significantly
higher on the left (adipose-derived stem cell-conditioned medium) side than on the right
(placebo) side (Fig 7).
DISCUSSION
This study used trichograms to objectively show the positive effects of adipose-derived
stem cell-conditioned medium on alopecia. To obtain accurate data, shaving and marking
the area for the trichogram is important. We believe that trichograms, particularly as used
67
ePlasty VOLUME 15
in this study, offer a reliable and useful method for assessing the treatment of alopecia,
although the method is semi-invasive for patients.
Figure 2. Changes in the number of hairs before
and after treatment in male and female patients.
*P < .01.
Figure 3. Changes in the number of hairs before
and after treatment in male patients with or
without finasteride administration. *P < .05.
Treatment with adipose-derived stem cell-conditioned medium was effective, even in
patients who did not take finasteride. We believe that this treatment may offer an alternative
to finasteride administration and thus appears particularly useful for female patients. Although
no significant difference in improvement of alopecia was seen between male patients
treated using adipose-derived stem cell-conditioned medium with and without finasteride
administration, we got the impression that the combination of adipose-derived stem cellconditioned
medium and finasteride is preferable to single treatment. The combination
therapy was effective in our previous study as well.6 We believe that hairs are regulated
by various factors, including androgen and cytokines. The efficacy of combination therapy
should be elucidated in a future study.
68
FUKUOKA ET AL
Figure 4. A 49-year-old male patient. (A) Before treatment. (B) During
treatment (4 months after initial treatment). (C) After treatment (10 months
after initial treatment). (D) Final follow-up (2 years and 1 month after initial
treatment).
Adipose-derived stem cell-conditioned medium is rich in growth factors such as vascular
endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor,
and insulin-like growth factor 1.2,9 Vascular endothelial growth factor controls hair growth
and follicle size through angiogenesis.10 Hepatocyte growth factor is involved in the cyclic
growth of hair follicles.11,12 Platelet-derived growth factor induces and maintains the anagen
phase of hair follicles.13 Insulin-like growth factor 1 controls the hair growth cycle
and differentiation of hair shafts.14 In treatment with adipose-derived stem cell-conditioned
medium, each growth factor seems likely to activate hair follicles and contribute to increasing
the number of hairs in patients with alopecia. Because growth factors dose-dependently
69
ePlasty VOLUME 15
affect cells, the dose dependence of the effects of adipose-derived stem cell-conditioned
medium on alopecia should be examined in a future study.
In the half-side comparison study, the finding that the number of hairs increased even
on the right (placebo) side was somewhat surprising. This result might suggest that the
injection itself activates hair growth via tissue injury, or that adipose-derived stem cellconditioned
medium injected on one side can affect the other side, perhaps through the
local circulation.
Figure 5. A 44-year-old female patient. (A) Before treatment. (B) After treatment (7
months after initial treatment). (C) Final follow-up (1 year and 10 months after initial
treatment).
Figure 6. Changes in the number of hairs before
and after treatment in the half-side comparison

Figure 6. Changes in the number of hairs before
and after treatment in the half-side comparison
study. *P < .05 and †P < .01.
70
FUKUOKA ET AL
Figure 7. Increases in the
number of hairs in the
half-side comparison study.
*P < .01.
Contraindications for adipose-derived stem cell-conditioned medium treatment are
similar to those for general mesotherapy, including local skin disease, inflammation, infection,
allergic disease, autoimmune disease, pregnancy, cancer, and current anticoagulant
therapy. The most common complication is pain during and after injection, but this can be
prevented or managed with supraorbital nerve block, occipital nerve block, local anesthesia,
cooling, or administration of nonsteroidal anti-inflammatory drugs.
In conclusion, treatment using adipose-derived stem cell-conditioned medium appears
highly effective for alopecia and may represent a new avenue of therapy for hair regeneration.
More details about adipose-derived stem cell-conditioned medium treatment, such as longterm
(over a period of years) effects and histological changes, should be elucidated in the
future.
REFERENCES
1. Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res.
2007;100:1249-60.
2. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose
stromal cells. Circulation. 2004;109:1292-8.
3. Suga H, Eto H, Shigeura T, et al. IFATS collection: fibroblast growth factor-2-induced hepatocyte growth
factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal
kinase-dependent mechanism. Stem Cells. 2009;27:238-49.
4. Wong CH, Yoo HG, Kwon OS, et al. Hair growth promoting effects of adipose tissue-derived stem cells. J
Dermatol Sci. 2010;57:134-7.
5. Festa E, Fretz J, Ryan B, et al. Adipocyte lineage cells contribute to the skin stem cell niche to drive hair
cycling. Cell. 2011;146:761-71.
6. Fukuoka H, Suga H. Hair regeneration treatment using stem cell conditioned medium. Jpn J Plast Surg.
2012;55:1083-9.
7. Fukuoka H, Suga H, Narita K, Watanabe R, Shintani S. The latest advance in hair regeneration therapy
using proteins secreted by adipose-derived stem cells. Am J Cosmet Surg. 2012;29:273-82.
8. Moon KM, Park YH, Lee JS, et al. The effect of secretory factors of adipose-derived stem cells on human
keratinocytes. Int J Mol Sci. 2012;13:1239-57.
9. Park BS, Kim WS, Choi JS, et al. Hair growth stimulated by conditioned medium of adipose-derived stem
cells is enhanced by hypoxia: evidence of increased growth factor secretion. Biomed Res. 2010;31:27-34.
71
ePlasty VOLUME 15
10. Yano K, Brown LF, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis.
J Clin Invest. 2001;107:409-17.
11. Jindo T, Tsuboi R, Takamori K, Ogawa H. Local injection of hepatocyte growth factor/scatter factor
(HGF/SF) alters cyclic growth of murine hair follicles. J Invest Dermatol. 1998;110:338-42.
12. Lindner G, Menrad A, Gherardi E, et al. Involvement of hepatocyte growth factor/scatter factor and met
receptor signaling in hair follicle morphogenesis and cycling. FASEB J. 2000;14:319-32.
13. Tomita Y, Akiyama M, Shimizu H. PDGF isoforms induce and maintain anagen phage of murine hair
follicles. J Dermatol Sci. 2006;43:105-15.
14. Weger N, Schlake T. Igf-1 signalling controls the hair growth cycle and the differentiation of hair shafts. J
mr. poseidon Inserito il - 12 gennaio 2017 : 13:30:26
ho guardato ma non capisco che novità sarebbe... un sito sui trapianti....
hairscience Inserito il - 11 gennaio 2017 : 18:21:54
beh che c'è da dire ?è un semplice trapianto di capelli o sbaglio ?
robbi76_ Inserito il - 11 gennaio 2017 : 17:41:35
siamo anni che perdiamo tempo scrivendo di tutto di piu per un pelo.. quì c'è la soluzione e nessuna la caga?

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